The focus of this review has been to examine the evidence to date that SRY is required for brain sexual differentiation. Adult gonadectomy to remove activational effects of steroid hormones results in XX individuals showing longer activity duration than those with XY chromosomes regardless of gonadal phenotype.
Cambridge University Press. Congenital adrenal hyperplasia: Longterm evaluation of feminizing genitoplasty and psychosocial aspects. In some species, such as the hermaphroditic clownfishsex differentiation can occur more than once as a response to different environmental cues,  offering an example of how sex differentiation does not always follow a typical linear path.
Thus, the still widespread assumption that the influence of sex is negligible retards progress in our field
The organizational-activational concept was formulated based initially on findings in guinea pigs Cavia porcellus. If the female is removed from the group, the largest male changes sex, i. These enzymes are primarily involved in dopamine synthesis and metabolism.
In the first weeks of life, a fetus has no anatomic or hormonal sexand only a karyotype distinguishes male from female. Endocrinology— A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female to male but not male to female transsexualism.
Its role in causing mosaicism of X gene effects in females, but not males, has, however, been emphasized 23
Epigenetic mechanisms are involved in sexual differentiation of the brain. The sex-specific effects of these differentiated social environments, no doubt pervasive and profound, have long been the purview of social psychology and not a topic integral to the study of brain sexual differentiation.
Reyhanian Caspillo, N. This condition can cause serious health issues later on, such as life-threatening kidney problems that need to be treated as soon as possible.