Velez and A. Liao S. Estrogen signaling in the CNS also contributes to body weight and adiposity, and thus at least indirectly to lipid and lipoprotein metabolism in animal models. Figure based on data from Sherwin and Gelfand, GPR30 is also involved in a wide range of physiological and pathological conditions, including some evidence for it playing a protective role in CVD View offers.
Estrogen Signaling In both males and females, E2 is derived from the aromatization of testosterone. A selective estrogen receptor alpha agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. Estrogen receptor alphalpha gene ESR1 PvuII and XbaI polymorphisms are associated to metabolic and proinflammatory factors in polycystic ovary syndrome.
Different splice variants of each receptor have been identified, and each exhibits distinct tissue-specific expression patterns and functions 10, In vivofemale mice with a hematopoietic deletion of ESR1 showed increased susceptibility for atherosclerosis with a twofold increase in atherosclerotic lesion area when fed a Western diet The publisher's final edited version of this article is available at Adv Exp Med Biol.
High testosterone level is associated with a low risk of diabetes in men, whereas it is associated with a high risk of diabetes in women [ , — ]. Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women. Genes involved in basic biochemical metabolism including insulin signaling, the urea cycle, glutamate metabolism, arginine and proline metabolism and amino-sugar metabolism had higher expression in the lower abdomen compared to the hip .